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EnglishCatalog No. : | IMB0020 |
Reactivity: | Human |
Applications: | WB; FCM; ELISA |
Gene Name: | CD3E |
Protein Name: | T-cell surface glycoprotein CD3 epsilon chain |
Human Gene Id: | 916 |
Swiss-Prot: | P07766 |
Formulation: | Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:500-1:2000 FCM: 1:200-1:400 ELISA: 1:10000 |
PurIF:ication: | Affinity purIF:ication |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. |
Subcellular Location.: | Cell membrane; Single-pass type I membrane protein. |
BiowMW: | nan |
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