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EnglishCatalog No. : | IMB0017 |
Reactivity: | Human;Rat;Mouse |
Applications: | IHC-p; |
Gene Name: | TGFB1 TGFB |
Protein Name: | Transforming growth factor beta-1, TGF-β1, TGF b |
Human Gene Id: | 7040 |
Swiss-Prot: | P01137 |
Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Source: | Monoclonal, Mouse |
Dilution: | IHC: 1:100-200 |
PurIF:ication: | The antibody was affinity-purIF:ied from mouse ascites by affinity-chromatography using specIF:ic immunogen. |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Background: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell prolIF:eration, dIF:ferentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. |
Subcellular Location.: | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix. [Transforming growth factor beta-1]: Secreted. |
BiowMW: | nan |
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