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EnglishCatalog No. : | IML0850 |
Reactivity: | Human |
Applications: | IHC-p; IF(paraffin section) |
Gene Name: | IRF4 MUM1 |
Protein Name: | MUM1 |
Human Gene Id: | 3662 |
Swiss-Prot: | Q15306 |
Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.168% sodium azide. |
Source: | Monoclonal, Mouse:IgG1, Kappa |
Dilution: | IHC-p: 1:100-200 IF: 1:100-500 |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | 0.45mg:mL |
Storage&Stability: | -20°C:1 year |
Background: | The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010], |
Subcellular Location: | Colon, Tonsil |
BiowMW: | nan |
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