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EnglishCatalog No. : | IML0838 |
Reactivity: | Human |
Applications: | IHC-p; IF(paraffin section) |
Gene Name: | TCL1A TCL1 |
Protein Name: | TCL1 |
Human Gene Id: | 8115 |
Swiss-Prot: | P56279 |
Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.154% sodium azide. |
Source: | Monoclonal, Mouse:IgG2b, Kappa |
Dilution: | IHC-p: 1:100-200 IF: 1:100-500 |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | 2.51mg:mL |
Storage&Stability: | -20°C:1 year |
Background: | Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-:CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010], |
Subcellular Location: | Tonsil, B-cell lymphoma |
BiowMW: | nan |
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