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TCL1 mouse mAb(ABT378)

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¥1900.00元/format:100ul

目录号:IML0838

库存:现货
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Catalog No. :IML0838
Reactivity:Human
Applications:IHC-p; IF(paraffin section)
Gene Name:TCL1A TCL1
Protein Name:TCL1
Human Gene Id:8115
Swiss-Prot:P56279
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.154% sodium azide.
Source:Monoclonal, Mouse:IgG2b, Kappa
Dilution:IHC-p: 1:100-200 IF: 1:100-500
Purification:The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration:2.51mg:mL
Storage&Stability:-20°C:1 year
Background:Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-:CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],
Subcellular Location:Tonsil, B-cell lymphoma
BiowMW:nan

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