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EnglishCatalog No. : | IML0163 |
Reactivity: | Human |
Applications: | IHC-p |
Gene Name: | CD38 |
Protein Name: | ADP-ribosyl cyclase 1 (EC 3.2.2.5) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38) |
Human Gene Id: | 952 |
Swiss-Prot: | P28907 |
Formulation: | Liquid in PBS containing, 0.5% BSA and 0.02% sodium azide. |
Source: | Monoclonal, Mouse:IgG1, Kappa |
Dilution: | Ready to use for IHC-p |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | nan |
Storage&Stability: | 4°C: 1 years |
Background: | The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. |
Subcellular Location: | Membranous |
BiowMW: | nan |
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