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EnglishCatalog No. : | IML0127 |
Reactivity: | Human |
Applications: | IHC-p; IF(paraffin section) |
Gene Name: | CD163 M130 |
Protein Name: | Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] |
Human Gene Id: | 9332 |
Swiss-Prot: | Q86VB7 |
Formulation: | Liquid in PBS containing, 0.5% BSA and 0.02% sodium azide. |
Source: | Monoclonal, Mouse:IgG1, Kappa |
Dilution: | Ready to use for IHC-p |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | nan |
Storage&Stability: | 4°C: 1 years |
Background: | The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin:haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Subcellular Location: | Membranous, Cytoplasmic |
BiowMW: | nan |
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