中文
EnglishCatalog No. : | IML0069 |
Reactivity: | Human |
Applications: | IHC-p; IF(paraffin section) |
Gene Name: | AMACR |
Protein Name: | Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase) |
Human Gene Id: | 23600 |
Swiss-Prot: | Q9UHK6 |
Formulation: | Liquid in PBS containing, 0.5% BSA and 0.02% sodium azide. |
Source: | Monoclonal, Mouse:IgG1, Kappa |
Dilution: | IHC-p: 1:100-1:200 IF: 1:50-1:200 |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | nan |
Storage&Stability: | 4°C: 1 years |
Background: | This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. |
Subcellular Location: | Cytoplasmic |
BiowMW: | nan |
SPECIES
APPLICATION
TITLE