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| Catalog No. ： | IML0062 |
| Reactivity： | Human |
| Applications： | IHC-p; IF(paraffin section) |
| Gene Name： | ERBB2 HER2 MLN19 NEU NGL |
| Protein Name： | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) |
| Human Gene Id： | 2064 |
| Swiss-Prot： | P04626 |
| Formulation： | Liquid in PBS containing, 0.5% BSA and 0.02% sodium azide. |
| Source： | Monoclonal, Mouse:IgG2b, Kappa |
| Dilution： | IHC-p: 1:100-1:200 IF: 1:50-1:200 |
| Purification： | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Concentration： | nan |
| Storage&Stability： | 4°C: 1 years |
| Background： | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654:Ile655, shown here. Amplification and:or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d. |
| Subcellular Location： | Membranous |
| BiowMW： | nan |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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