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EnglishCatalog No. : | IML0015 |
Reactivity: | Human |
Applications: | IHC-p; WB |
Gene Name: | CD3E T3E |
Protein Name: | CD3 |
Human Gene Id: | 916 |
Swiss-Prot: | P07766 |
Formulation: | Liquid in PBS containing, 0.5% BSA and 0.02% sodium azide. |
Source: | Monoclonal, Mouse:IgG2a, Kappa |
Dilution: | IHC-p: 1:100-200 |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | nan |
Storage&Stability: | 4°C: 1 years |
Background: | The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha:beta and gamma:delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. |
Subcellular Location: | Membranous |
BiowMW: | nan |
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