Reactivity

Human; Mouse

Applications

IHC-p; IF/ICC; ELISA

Alternative Names

Laminin subunit alpha-2; Laminin M chain Laminin-12 subunit alpha Laminin-2 subunit alpha Laminin-4 subunit alpha Merosin heavy chain; LAMA2

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.07% sodium azide.

Source

Rabbit

Dilution

IF: 1:200-1:1000; IF:1:50-1:200; ELISA: 1:40000

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Storage&Stability

Store at 4℃ short term. Aliquot and store at -20℃ long term. Avoid freeze-thaw cycles.

Subcellular Location

-

MW

~ 343 kDa

Background

laminin subunit alpha 2(LAMA2) Homo sapiens Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008].

Swiss-Prot

P24043