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| Catalog No. ： | IPH2264 |
| Reactivity： | Human;Mouse; |
| Applications： | WB, ELISA, IHC |
| Gene Name： | JAK2 |
| Protein Name： | Jak2 (Tyr1008) |
| Human Gene Id： | 3717 |
| Swiss-Prot： | O60674 |
| Formulation： | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source： | Polyclonal, Rabbit |
| Dilution： | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 |
| Purification： | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Background： | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. |
| Subcellular Location： | Nucleus, PML body. Cytoplasm. Nucleus. Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). [SirtT1 75 kDa fragment]: Cytoplasm . Mitochondrion. |
| BiowMW： | 130KD |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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